Brain Metabolism and Neurotransmission
Main Lab Location:
Osaka Univ. (Suita Campus)
Director, PET Molecular Imaging Center, Osaka University Graduate School of Medicine PI, IFReC, Osaka University
2-2 Yamadaoka, Suita City Osaka, 565-0871
My research is in the field of nuclear medicine, specializing in the development of integrated PET/MRI systems and other new neuroimaging technologies.
Information is transmitted between neurons through the synthesis, release and receptor binding of neurotransmitters in a synapse. It is possible to simultaneously measure the dynamics and receptor occupancy of labeled neurotransmitters and the corresponding change in blood flow by using electric excitation and an integrated PET/MRI system. Since developing our original integrated PET/MRI system, our research focuses on analyzing the intra-cerebral neurotransmission through observations of neurotransmitter, blood and energy metabolism behaviour. Such systems create a new fusion of morphological and functional imaging.
Simultaneous imaging using Si-PM-based PET and MRI for development of an integrated PET/MRI system. Yamamoto, S., Watabe, T., Watabe, H., Aoki, M., Sugiyama, E., Imaizumi, M., Kanai, Y., Shimosegawa, E., Hatazawa, J. Physics in Medicine and Biology, vol. 57, no. 2, pp. N1-N13, 2012
Interference between PET and MRI sub-systems in a silicon-photomultiplier-based PET/MRI system. Yamamoto, S., Watabe, H., Kanai, Y., Aoki, M., Sugiyama, E., Watabe, T., Imaizumi, M., Shimosegawa, E., Hatazawa, J. Physics in Medicine and Biology, vol. 56, no. 13, pp. 4147-4159, 2011
Development of a high-resolution Si-PM-based gamma camera system Yamamoto, S., Watabe, H., Kanai, Y., Imaizumi, M., Watabe, T., Shimosegawa, E., Hatazawa, J. Physics in Medicine and Biology, vol. 56, no. 23, pp. 7555-7567, 2011