Events

  • HOME
  • News & Events
  • Forthcoming events
  • Cell-type-specific patterned activities specify gene expression patterns for olfactory circuit formation -Neurons that fire in the same pattern wire together-

Haruki Takeuchi: “Cell-type-specific patterned activities specify gene expression patterns for olfactory circuit formation -Neurons that fire in the same pattern wire together-”

 

October 25, 2019  Friday Lunch Seminar
12:15 〜 13:00

CiNet 1F Conference Room
“Cell-type-specific patterned activities specify gene expression patterns for olfactory circuit formation -Neurons that fire in the same pattern wire together-”
Haruki Takeuchi

Graduate School of Pharmaceutical Sciences
The University of Tokyo

Host PI: Yuji Ikegaya

Abstract:

The development of precise neural circuits is initially directed by genetic programming and subsequently refined by electrical neural activity. The most prevailing model for the activity-dependent development of neural circuits postulates the interaction between pre- and post-synaptic neurons. In Hebbian plasticity, the correlated activity of pre- and post-synaptic neurons strengthens synaptic connections, whereas uncorrelated or lack of activity weakens them. However, the olfactory map develops even in mutant mice lacking synaptic partners, suggesting another mechanism for the olfactory map formation. In this seminar, I would like to propose a novel activity-dependent mechanism in which cell-type-specific patterned activity contributes to the olfactory map refinement through orchestrating gene expression of various axon-sorting molecules.

References:
1. ※Nakashima A, ※Ihara N. et al. Science (article), DOI: 10.1126/science.aaw5030 (2019)
2. Ihara N, Nakashima A. et al. Eur. J. Neurosci Vol.44, 1998-2003 (2016)
3. ※Nakashima A, ※Takeuchi H. et al. Cell, Vol.154 1314-1325 (2013)
4. ※Takeuchi H, ※Inokuchi K. et al. Cell, Vol.141 1056-1067 (2010)
5. ※Serizawa S, ※Miyamichi K, ※Takeuchi H. et al. Cell, Vol.127 1057-1069 (2006)

※ equally contributed

About CiNet's Friday Lunch Seminars:
The Friday Lunch Seminar is CiNet's main regular meeting series, held every week at 12:15 in the beautiful main lecture theatre on the ground floor at CiNet. The talks are typically 40mins long and orientated towards an inter-disciplinary audience. They are informal, social, and most people bring their own lunch to eat during the talk. They are open to anyone who is feeling curious and wants to come, regardless of where you work.