Friday Lunch Seminar: Ryota Kobayashi: “Estimating synaptic connectivity from parallel spike trains” (On-line for CiNet members only: Sign-up required)

Friday Lunch Seminar (English)

November 19, 2021
12:15 〜 13:00

Talk Title:Estimating synaptic connectivity from parallel spike trains

Ryota Kobayashi
Associate Professor
Graduate School of Frontier Sciences
The University of Tokyo

Host PI: Naoki Wakamiya

We develop two methods (GLMCC and CoNNECT) for estimating synaptic connectivity in units of postsynaptic potentials from parallel spike trains. Here we extend the cross-correlation method (Aertsen and Gerstein, 1985) to incorporate the large fluctuations in neural signals in vivo. We verified these methods by applying them to simulated and experimental data. The proposed method allows researchers to reconstruct a circuit diagram of a neural network, which offers an opportunity to elucidate computational mechanisms based on the structure.

Our algorithms are freely available on the webpages: 1) and 2)