CiNet Monthly Seminar

2025年5月22日（木）
16:00-17:00
CiNet棟大会議室にて開催いたします。

演題：Reactivation, transformation, and impairment of memory traces in the human brain

フランス Ruhr University Bochum
Faculty of Psychology
Institute for Cognitive Neuroscience
Professor
Nikolai Axmacher

担当 : Rob Mok

Abstract:
Experiences are stored in the brain via memory traces, or engrams. Network-level signatures of these traces – “engram patterns” – can be extracted from patterns of EEG oscillations and fMRI BOLD activity. In the first part of my talk, I will show how the reactivation of engram patterns supports diverse functions from short-term memory maintenance to long-term memory retrieval and consolidation. However, it is commonly assumed that memory is not a veridical reproduction of past experiences but involves substantial transformations. In the second part, I will describe how memory traces are transformed into representational formats that are conducive for the specific task demands, and that can be quantitatively assessed via deep neural networks. In the final section, I will describe how distortions and impairments of spatial memory and navigation provide a cognitive marker of early stages of Alzheimer’s disease.