CiNet Monthly Seminar （英語で開催）
On-lineで開催いたします。

2021年7月26日（月）
10:00-11:30
JST (GMT + 9:00)

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申込締め切り：7月21日 正午 JST (GMT + 9:00)
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“How does the brain decide to make an effort? Dissecting the role of the striatum in motivation and clinical implications”

Emory University
PhD student
Shosuke Suzuki

担当 : 春野雅彦

Abstract:
Physical effort is a critical resource that organisms must invest wisely to ensure survival. In humans, maladaptive allocation of effort is commonly observed in psychological disorders, including Major Depressive Disorder. Understanding how the brain allocates effort in pursuit of various goals is therefore a fundamental question for both clinical and behavioral neuroscience. Thus far, decades of research in animals and humans have suggested a critical role for the ventral striatum in encoding cost/benefit value signals, yet this effect has strikingly been absent during neuroimaging paradigms that assess choices related to physical effort. Here, we review findings in the role of the striatum in motivation and its relationship with depression from recent work combining multimodal imaging, naturalistic paradigms, and computational modeling. Our work suggests critical spatial distinctions within corticostriatal circuits that include neighboring subregions of the striatum encoding different aspects of effort—invigoration, movement, and value. We further discuss the sensitivity of these striatal regions to depression and potential role of the striatum with respect to depressive symptoms.