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NICT-IFReC Joint Seminar: Yuka Sasaki “Opponent neurochemical and functional processing in NREM and REM sleep in visual perceptual learning” 

 

NICT-IFReC Joint Seminar

2019年12月13日(金)
16:00-17:00
会場: CiNet 1F 大会議室

講演タイトル:”Opponent neurochemical and functional processing in NREM and REM sleep in visual perceptual learning”

講師:
Brown University
Professor
Yuka Sasaki

主催:
国立研究開発法人情報通信研究機構 脳情報通信融合研究センター(CiNet)
大阪大学 免疫学フロンティア研究センター (IFReC)

Abstract:
Sleep is beneficial for learning. However, whether NREM or REM sleep facilitates learning, whether the learning facilitation results from plasticity increases or stabilization and whether the facilitation results from learning-specific processing are all controversial. Here, after training on a visual task we measured the excitatory and inhibitory neurochemical (E/I) balance, an index of plasticity measured by magnetic resonance spectroscopy in human visual areas, for the first time, while subjects slept. Off-line performance gains of presleep learning were associated with the E/I balance increase during NREM sleep, which also occurred without presleep training. In contrast, increased stabilization was associated with decreased E/I balance during REM sleep only after presleep training. These indicate that the above-mentioned issues are not matters of controversy but reflect opposite neurochemical processing for different roles in learning during different sleep stages: NREM sleep increases plasticity leading to performance gains independently of learning, while REM sleep decreases plasticity to stabilize learning in a learning-specific manner.