{"id":2027,"date":"2022-09-14T21:48:00","date_gmt":"2022-09-14T12:48:00","guid":{"rendered":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/?post_type=event&#038;p=2027"},"modified":"2022-10-12T10:22:25","modified_gmt":"2022-10-12T01:22:25","slug":"20220914_4027","status":"publish","type":"event","link":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/event\/20220914_4027\/","title":{"rendered":"\uff1cCiNet \u30e1\u30f3\u30d0\u30fc\u3092\u5bfe\u8c61\u306bon-line \u958b\u50ac\uff1eFriday Lunch Seminar \u5c0f\u5c71\u5185 \u5b9f\uff1a\u201cQuantitative activation-induced manganese-enhanced MRI (qAIM-MRI) can visualize the history of neural activities in the whole brain of a freely moving animal\u201d"},"content":{"rendered":"\n<p>2022\u5e749\u670830\u65e5\u3000\u3000Friday Lunch Seminar \uff08\u82f1\u8a9e\u3067\u958b\u50ac\uff09<br>12:15&nbsp;\u301c&nbsp;13:00<br>On-line\u3067\u958b\u50ac\u3044\u305f\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p>\u6f14\u984c\uff1aQuantitative activation-induced manganese-enhanced MRI (qAIM-MRI) can visualize the history of neural activities in the whole brain of a freely moving animal<\/p>\n\n\n\n<p>\u5927\u962a\u5927\u5b66\u5927\u5b66\u9662<br>\u533b\u5b66\u7cfb\u7814\u7a76\u79d1<br>\u6559\u6388<br>\u5c0f\u5c71\u5185 \u5b9f<\/p>\n\n\n\n<p>\u62c5\u5f53PI\uff1a<a href=\"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/people\/2014307\/\">\u5409\u5ca1 \u82b3\u89aa<\/a><\/p>\n\n\n\n<p>Abstract:<br>The brain has a complex hierarchical structure, and information is processed through interactions between and within hierarchies.<br>Therefore, directly linking phenotypes, the output results of the brain, to measurement results in one part of the brain involves a logical fallacy. This fallacy is called the mereological fallacy. To avoid this fallacy, we have constructed a multi-scale, multi-modal measurement system and applied it to neuroscience research. In the system, we employ quantitative activation-induced manganese-enhanced MRI (qAIM-MRI) as an in vivo noninvasive whole-brain neural activity measurement method.<br>Manganese ion (Mn^2+) can pass through calcium (Ca^2+) channels and is extruded very slowly from the cell. Ca^2+ channels open more frequently in highly active neurons; hence, in the presence of Mn^2+ in the extracellular solution, highly active neurons accumulate larger amounts of Mn^2+ than weakly active neurons. Therefore, Mn^2+ is a surrogate marker of Ca^2+ influx in excitable tissues. A paramagnetic ion, Mn^2+ shortens the longitudinal relaxation time (T1) of protons (H^+), and the longitudinal relaxation rate R1 (=1\/T1) is proportional to Mn^2+ concentration. Thus, [Mn^2+] can be quantified by the R1 value calculated from the T1 value. Based on these ideas, AIM-MRI can use R1 to measure neural activity changes in a freely moving subject with the advantage of being insensitive to blood hemodynamics. In this seminar, I will show the Mn^2+ dynamics in the brain for optimizing the experimental protocols for AIM-MRI and will introduce some application results of AIM-MRI studies.<\/p>\n","protected":false},"featured_media":0,"template":"","acf":[],"_links":{"self":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/wp-json\/wp\/v2\/event\/2027"}],"collection":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/wp-json\/wp\/v2\/event"}],"about":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/wp-json\/wp\/v2\/types\/event"}],"wp:attachment":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/wp-json\/wp\/v2\/media?parent=2027"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}