{"id":1724,"date":"2019-03-14T16:12:00","date_gmt":"2019-03-14T07:12:00","guid":{"rendered":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/?p=1724"},"modified":"2022-08-27T09:48:07","modified_gmt":"2022-08-27T00:48:07","slug":"20190215_4189","status":"publish","type":"event","link":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/event\/20190215_4189\/","title":{"rendered":"32nd CiNet Monthly Seminar: Fahmeed Hyder \u201cSalient metabolic features of human brain function\u201d"},"content":{"rendered":"\n<p><strong>CiNet Monthly Seminar<\/strong><\/p>\n\n\n\n<p>2019\u5e743\u670814\u65e5\uff08\u6728\uff09<br>16:00 ~ 17:00<br>\u4f1a\u5834 \uff1a CiNet\u30001F\u3000\u5927\u4f1a\u8b70\u5ba4<\/p>\n\n\n\n<p>\u201cSalient metabolic features of human brain function\u201d<\/p>\n\n\n\n<p>Fahmeed Hyder<br>Professor, Biomedical Engineering<br>Professor, Radiology &amp; Biomedical Imaging Technical Director<br>MRRC preclinical scanners Program Director<br>QNMR Core Center Yale University<\/p>\n\n\n\n<p>\u62c5\u5f53 :&nbsp;<a href=\"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/people\/2014465\/\">\u9ec4\u7530\u80b2\u5b8f<\/a>\uff08PI\uff09<\/p>\n\n\n\n<p>Abstract<\/p>\n\n\n\n<p>We are exploring metabolic demands of (de)activation in relation to the resting human brain. In goal-directed fMRI scans BOLD signal is greater (or activated) compared to the baseline (or resting) condition in the frontoparietal \u201ctask-positive\u201d network (TPN), whereas BOLD signal is reduced (or deactivated) in the \u201ctask-negative\u201d network (TNN) or default mode network (DMN) and which includes areas like posterior cingulate. During a visual task (flashing checkerboard, 8Hz, visual angle 15\u00d718\u00b0) lactate\/BOLD signal increases are observed in the visual cortex, suggesting sensory-related aerobic glycolysis rise in non-DMN (or TPN) areas. With a cognitive task (audio-emotion portrayals with eyes closed) lactate\/BOLD signal decreases are detected in posterior cingulate, signifying cognition-related aerobic glycolysis reduction in DMN (or TNN) regions. Without stimuli spontaneous BOLD signal fluctuations also reveal negatively- and positively-correlated regions, which are respectively known as DMN and non-DMN areas. However both DMN and non-DMN areas have similar levels of glucose oxidation at rest (non-sedated, eyes closed). These results indicate lack of regional specialization for aerobic glycolysis during activation, deactivation, and at rest, signifying importance of brain-wide oxidative metabolism for healthy network function in the adult human brain.<\/p>\n","protected":false},"featured_media":0,"template":"","acf":[],"_links":{"self":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/wp-json\/wp\/v2\/event\/1724"}],"collection":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/wp-json\/wp\/v2\/event"}],"about":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/wp-json\/wp\/v2\/types\/event"}],"wp:attachment":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/japanese\/wp-json\/wp\/v2\/media?parent=1724"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}