{"id":4360,"date":"2025-11-14T14:29:27","date_gmt":"2025-11-14T05:29:27","guid":{"rendered":"http:\/\/cinetjp-static3.nict.go.jp\/english\/?post_type=event&#038;p=4360"},"modified":"2025-12-03T11:34:55","modified_gmt":"2025-12-03T02:34:55","slug":"20260128_0090","status":"publish","type":"event","link":"http:\/\/cinetjp-static3.nict.go.jp\/english\/event\/20260128_0090\/","title":{"rendered":"82nd CiNet Monthly Seminar:   Nahoko Kuga-Sasaki  &#8220;Neurophysiological mechanisms of stress regulation through brain-body interactions&#8221;\u00a0(On-line for CiNet members only)"},"content":{"rendered":"\n<p>CiNet Monthly Seminar<\/p>\n\n\n\n<p>January 28 (Wed.), 2026<br>14:00-15:00 (JST)<br>On-line, also projected on the screen in the Conference Room<br><br>Talk title: Neurophysiological mechanisms of stress regulation through brain-body interactions<\/p>\n\n\n\n<p>Nahoko Kuga-Sasaki<br>Assistant Professor<br>Frontier Research Institute for Interdisciplinary Sciences<br>Tohoku University<\/p>\n\n\n\n<p>Host :&nbsp;<a rel=\"noreferrer noopener\" href=\"https:\/\/cinet.jp\/english\/people\/20182454\/\" target=\"_blank\">Atsushi Yokoi<\/a><br><br>Abstract:<br>Emotional states are influenced not only by brain activity but also by interoceptive signals from peripheral organs. For example, changes in heart rate or gut motility have been associated with anxiety and depressive disorders. In addition, electrical stimulation of the vagus nerve, a major pathway conveying interoceptive signals to the brain, has emerged as a potential therapeutic approach for depression. However, the mechanisms by which peripheral organ activity influences emotional regulation remain poorly understood. To address this issue, we established an electrophysiological recording system that enables simultaneous recordings of peripheral signals (electrocardiogram, gut motility, respiration, and vagus nerve activity) and brain activity in freely moving rodents. Using this system, we found that activity in the prefrontal cortex and amygdala, particularly in the 2\u20134 Hz and 20\u201330 Hz oscillations, negatively and positively correlates with vagus nerve activity, respectively, during behaviors related to social interaction and anxiety. This correlation was reduced in mice exhibiting strong anxiety-like behavior following social defeat stress, but vagus nerve stimulation restored both the correlation and the stress-induced behavioral changes. Beyond these peripheral\u2013brain interactions, we are investigating how interoceptive signals modulate stress-related memory processes. Our previous study revealed that animals exhibiting more frequent hippocampal sharp-wave ripples, which are related to memory consolidation, following stressful experiences showed greater reductions in social behavior. Our current work extends this line of research, and we have found that the paraventricular nucleus of the thalamus, a major hub linking peripheral physiological states to the brain, influences both hippocampal ripple activity and stress-related behavioral responses. These findings suggest that interoception may influence emotional processes through the paraventricular nucleus of the thalamus\u2013hippocampal pathways.<\/p>\n","protected":false},"featured_media":0,"template":"","acf":[],"_links":{"self":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/english\/wp-json\/wp\/v2\/event\/4360"}],"collection":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/english\/wp-json\/wp\/v2\/event"}],"about":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/english\/wp-json\/wp\/v2\/types\/event"}],"version-history":[{"count":9,"href":"http:\/\/cinetjp-static3.nict.go.jp\/english\/wp-json\/wp\/v2\/event\/4360\/revisions"}],"predecessor-version":[{"id":4375,"href":"http:\/\/cinetjp-static3.nict.go.jp\/english\/wp-json\/wp\/v2\/event\/4360\/revisions\/4375"}],"wp:attachment":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/english\/wp-json\/wp\/v2\/media?parent=4360"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}