Ikuhiro Kida<\/a>\u00a0(PI)<\/p>\n\n\n\nAbstract:<\/p>\n\n\n\n
We are exploring metabolic demands of (de)activation in relation to the resting human brain. In goal-directed fMRI scans BOLD signal is greater (or activated) compared to the baseline (or resting) condition in the frontoparietal \u201ctask-positive\u201d network (TPN), whereas BOLD signal is reduced (or deactivated) in the \u201ctask-negative\u201d network (TNN) or default mode network (DMN) and which includes areas like posterior cingulate. During a visual task (flashing checkerboard, 8Hz, visual angle 15\u00d718\u00b0) lactate\/BOLD signal increases are observed in the visual cortex, suggesting sensory-related aerobic glycolysis rise in non-DMN (or TPN) areas. With a cognitive task (audio-emotion portrayals with eyes closed) lactate\/BOLD signal decreases are detected in posterior cingulate, signifying cognition-related aerobic glycolysis reduction in DMN (or TNN) regions. Without stimuli spontaneous BOLD signal fluctuations also reveal negatively- and positively-correlated regions, which are respectively known as DMN and non-DMN areas. However both DMN and non-DMN areas have similar levels of glucose oxidation at rest (non-sedated, eyes closed). These results indicate lack of regional specialization for aerobic glycolysis during activation, deactivation, and at rest, signifying importance of brain-wide oxidative metabolism for healthy network function in the adult human brain.<\/p>\n","protected":false},"featured_media":0,"template":"","acf":[],"_links":{"self":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/english\/wp-json\/wp\/v2\/event\/1693"}],"collection":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/english\/wp-json\/wp\/v2\/event"}],"about":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/english\/wp-json\/wp\/v2\/types\/event"}],"wp:attachment":[{"href":"http:\/\/cinetjp-static3.nict.go.jp\/english\/wp-json\/wp\/v2\/media?parent=1693"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}