Hiroki Hamanaka

Main Lab Location:

Osaka Univ. (Suita Campus)

Specific Research Topic:

Molecular biology, Neuroengineering

Mailing Address:

 1-4 Yamadaoka, Suita City, Osaka, 565-0871, Japan

I am interested in developing new technologies for comprehensive functional and structural brain mapping. I have been working on various viral vectors including rabies virus to trace anatomical circuits at long and intermediate-range scales. To link brain activity to behavior, I am trying to apply precise interventional tools such as optogenetics, chemogenetics, and electromagnetic modulation to manipulate neural circuit activity. Another approach for functional mapping is to develop novel devices to record neuronal activity at a variety of spatial and temporal scales.

Currently I am collaborating with researchers in the field of materials and systems engineering to develop a new type of electrode and a module for wireless recording in freely moving marmosets. The ultimate goal of my research is to understand the human brain and treat its disorders by developing and combining a variety of new technologies.

Selected Publications:

Wickersham, I.R., Sullivan, H.A., Pao, G.M., Hamanaka, H., Goosens, K.A., Verma, I.M., Seung, H.S. (2015) Lentiviral vectors for retrograde delivery of recombinases and transactivators. Cold Spring Harb Protoc. 2015(4): 368-374.

Johansen J.P,, Diaz-Mataix L., Hamanaka H., Ozawa T., Ycu E., Koivumaa J., Kumar A., Hou M., Deisseroth K., Boyden E.S., LeDoux J.E. (2014) Hebbian and neuromodulatory mechanisms interact to trigger associative memory formation. Proc. Natl. Acad. Sci. USA 111, 5584-5592.

Johansen, J.P., Hamanaka, H., Monfils, M.H., Behnia, R., Deisseroth, K., Blair, H.T., LeDoux, J.E. (2010) Optical activation of lateral amygdala pyramidal cells instructs associative fear learning. Proc. Natl. Acad. Sci. USA 107, 12692-12697.

Mann, K.M., Thorngate, F.E., Katoh-Fukui, Y., Hamanaka, H., Williams, D.L., Fujita, S., and Lamb, B.T. (2004) Independent effects of APOE on cholesterol metabolism and brain Aß levels in an Alzheimer disease mouse model. Hum. Mol. Genet. 13, 1959-1968.

Hamanaka, H., Katoh-Fukui, Y., Suzuki, K., Kobayashi, M., Suzuki, R. Motegi, Y., Nakahara, Y., Takeshita, A., Kawai, M., Ishiguro, K., Yokoyama, M., and Fujita, S.C. (2000) Altered cholesterol metabolism in human apolipoprotein E4 knock-in mice. Hum. Mol. Genet. 9, 353-361.