Principal investigators

Aya Nakae

Pain and Anesthesia

Main Lab Location:

CiNet (Main bldg.)

Mailing Address:

1-3, Yamadaoka, Suita, Osaka, 565-0871

My research focuses on consciousness and pain.

Pain is closely related with consciousness, and its perception by the human brain depends on multiple complex factors. Indeed, it is very difficult to divide causes and consequences related to pain processing. Identification of causes would allow us to develop novel analgesics, with the eventual hope of reducing the suffering and improving the quality of life of very many people.

I have studied pain models in small animals using large-scale genetic (mRNA, methylated DNA, and miRNA) sequencing methods, to develop an objective biomarker. More recently, I began a new research program to study anesthesia and pain using high resolution brain imaging (PET and MRI) in small animals. Ultimately, my research aims to develop an understanding of pain and anaesthesia that spans multiple levels: from brain systems to molecular mechanisms.

As a clinician, I also aim to develop translational insights that can be applied to real clinical problems.

Selected Publications:

Nakae A, Nakai K, Tanaka T, Hosokawa K, Mashimo T. Serotonin 2C receptor alternative splicing in a spinal cord injury model. Neurosci Lett. 2013 ; 532:49-54.

Nakae A, Nakai K, Yano K, Hosokawa K, Shibata M, Mashimo T. The animal model of spinal cord injury as an experimental pain model. J Biomed Biotechnol.2011;2011:939023.

Murray KC, Nakae A, Stephens MJ, Rank M, D'Amico J, Harvey PJ, Li X, Harris RL, Ballou EW, Anelli R, Heckman CJ, Mashimo T, Vavrek R, Sanelli L, Gorassini MA, Bennett DJ, Fouad K. Recovery of motoneuron and locomotor function after spinal cord injury depends on constitutive activity in 5-HT2C receptors. Nat Med.2010 ; 16(6):694-700.