Principal investigators

Yoshichika Yoshioka

Functional Imaging Technologies

Main Lab Location:

CiNet (Main bldg.)



Mailing Address:

4-1 Yamadaoka, Suita, Osaka 565-0871



My lab’s main interest is to develop visualization techniques to unveil the functions of integrated biological systems such as neural and immune systems. Application of innovative imaging technologies for neurosciences as well as other fields is important to understand dynamic biological functions in humans.

One of the foci of our research is noninvasive visualization of crosstalk among neural, immune and endocrine systems. These systems relate with each other closely by direct pathways and/or via humoral factors. This correlation is very important for not only brain function but also psychiatric state, emotion, learning, growth, maturation, immunity, homeostasis, and so on. Noninvasive techniques are desirable to identify the real crosstalk among them because these systems are influenced easily by several experimental maneuvers.

In particular, magnetic resonance provides diverse information about anatomy, function and metabolism in humans and animals. We have been trying to develop high-resolution, non-invasive and repeatable new functional imaging techniques with ultra high-field magnetic resonance scanners.

Our two 11.7 T ultra high-field MR scanners (at CiNet and IFReC) for small animals and a 7.0 T (at CiNet) scanner for humans can provide high resolution and high specific information of biological systems. Our recent progress of MRI technologies in humans can allow us to image human brain temperatures noninvasively and to estimate the dynamical brain energy changes during activations at physiological conditions. In animal studies, we can visualize the dynamical immune responses and the immune cell migrations at a single cell level in situ.

Join us to visualize the integrated functions of humans anyone could not see!!

Selected Publications:

Kashiwagi Y, Rokugawa T, Yamada T, Obata A, Watabe H, Yoshioka Y, Abe K. Pharmacological MRI Response to a Selective Dopamine Transporter Inhibitor, GBR12909, in Awake and Anesthetized Rats. Synapse 2015; 69: 203-212.

Mori Y, Chen T, Fujisawa T, Kobashi S, Ohno K, Yoshida S, Tago Y, Komai Y, Hata Y, Yoshioka Y: From cartoon to real time MRI: in vivo monitoring of phagocyte migration in mouse brain. Scientific Reports 2014; 4: 6997. DOI: 10.1038/srep06997.

Inui T, Inui-Yamamoto C, Yoshioka Y, Ohzawa I, Shimura T: Activation of efferents from the basolateral amygdala during the retrieval of conditioned taste aversion. Neurobiology of Learning and Memory 2013; 106: 210-220.

Saito H, Ogasawara K, Nishimoto H, Yoshioka Y, Murakami H, Fujiwara S, Sasaki M, Kobayashi M, Yoshida K, Kubo Y, Beppu T, Ogawa A: Postoperative Changes in Cerebral Metabolites Associated with Cognitive Improvement and Impairment after Carotid Endarterectomy: A 3T Proton MR Spectroscopy Study. Am J Neuroradiol 2013; 34: 976-982.

Satoh T, Kidoya H, Naito H, Yamamoto M, Takemura N, Nakagawa K, Yoshioka Y, Morii E, Takakura N, Takeuchi O, Akira S: Critical role of Trib1 in differentiation of tissue-resident M2-like macrophages. Nature 2013; 495: 524-528.

Short Biography:

1983 Dr Sci in Physical Chemistry, Osaka University
1984 Assistant Professor, Physiology, Iwate Medical University
1988 Lecturer, Physiology, Iwate Medical University
2004 Lecturer, High Field MRI Research Institute, Iwate Medical University
2007 Associate Professor, High Field MRI Research Institute, Iwate Medical University
2008 Professor, Immunology Frontier Research Center (WPI-IFReC), Osaka University

Announcements / News:

Dr. Yuki Mori is awarded "Best Poster Award" at the 41st Japanese Society for Magnetic Resonance in Medicine (JSMRM) Annual Meeting (19-21 Sept., 2013, Tokushima, Japan). The presentation title is "Sequential MRI Monitoring of Peripheral Macrophage Infiltration into the Brain using Iron Oxide Nano-particles". Co-authors are Ting Chen, Zhenyu Cheng, Koji Ohno, Shinichi Yoshida, Yosiyuki Tago, Masaki Fukunaga, and Yoshichika Yoshioka.

Japanese Society for Magnetic Resonance in Medicine (JSMRM) announced that Dr Yuki Mori is awarded "Bayer International Publication Award". The presentation title is "Temporal Changes in Lower-Lumbar Spinal Cord in EAE Mouse". Co-authors are Masaaki Murakami, Yasunobu Arima, Dasong Zhu, and Yoshichika Yoshioka.

Lab Members:

・Chizuko Inui
・Fuminori Sugihara
・Takashi Nakagawa
・Shunrou Fujiwara
・Hiroshi Sato

・Shota Yoshida
・Ting Chen
・Kiyoyuki Osugi

Technician & Secretary
・Noriko Kitagaki