Toshiki Yoshimine

Main Lab Location:

Osaka Univ. (Suita Campus)

Specific Research Topic:

Clinical Brain Machine Interfaces

Other Affiliations:

Specially Appointed Professor
Global Center for Medical Engineering and Informatics
Osaka University

Mailing Address:

2-2 Yamadaoka, Suita City Osaka, 565-0871

My research focuses on the clinical development of human brain machine interfaces (BMIs).

Brain-machine interfaces involve decoding electrical signals form the brain to control external devices. For example, in paralysed patients, an important clinical goal is to be able record and decode activity from the motor cortex to control actions of a robotic limb, so that motor function can be recovered. My lab develops invasive BMI systems using surface electrocortical implants placed directly on the surface of the brain. We have successfully implanted these in patients, and continue to develop all aspects of these systems, including clinical, hardware and software components.

Currently we are developing a new fully implantable wireless system. Ultimately, we aim to develop general motor BMI systems that can be used in a range of patients with conditions such as tetraplegia, ALS and lock-in syndrome, to support restoration of motor and communication functions.

Selected Publications:

Hirata M, Matsushita K, Suzuki T, et al (2011) A fully-implantable wireless system for human brain-machine interfaces using brain surface electrodes: W-HERBS. IEICE Trans Commun E94-B:2448-2453.

Sugata H, Goto T, Hirata M, et al (2012) Neural decoding of unilateral upper limb movements using single trial MEG signals. Brain Res 1468:29-37.

Sugata H, Goto T, Hirata M, et al (2012) Movement-related neuromagnetic fields and performances of single trial classifications. Neuroreport 23:16-20.

Yanagisawa T, Yamashita O, Hirata M, et al (2012) Regulation of motor representation by phase-amplitude coupling in the sensorimotor cortex. J Neurosci 32:15467-15475.

Yanagisawa T, Hirata M, Saitoh Y, et al (2012) Electrocorticographic control of a prosthetic arm in paralyzed patients. Ann Neurol 71:353-361.

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