James Kolasinski: “Somatosensory plasticity at 7T : from neurochemicals and maps to perception”
CiNet 1F 大会議室
The ordered somatotopy of primary somatosensory cortex (SI) has long served as a model system for studies of both cortical organization and reorganization. To date studies of the fine-grain detail of such cortical maps has remained largely the domain of electrophysiologists working with animal models. However, with recent advances in the spatial resolution of fMRI, afforded by the advent of 7 tesla systems, it is now feasible to resolve the detailed functional architecture of SI at the level of individual human participants. Here I present the results of a series of studies focused on single-subject mapping of the cortical representations of the digits (fingers) in SI. Specifically, I will outline the mapping approach applied and observed inter-subject variability of these maps in SI, before going on to discuss evidence for extremely short-term experience-dependent plasticity in these representations. Finally, I will aim to put these maps into context, exploring the relationship of cortical somatotopy with MRS-derived measures of neurochemical concentrations, and perceptual measures of tactile function.