Takashi Ueguchi

Main Lab Location:

CiNet (Main bldg.)

Specific Research Topic:

Medical Physics

Other Affiliations:

Guest Associate Professor
Graduate School of Frontier Biosciences, Osaka University





Mailing Address:

1-4 Yamadaoka, Suita, Osaka 565-0871, Japan



My research interests are in medical physics, particularly in the areas of diagnostic radiology and nuclear medicine, with an emphasis on advanced  imaging techniques.

Ultra-high-field (7 Tesla) MR imaging allows us to analyze structures and functions of the human brain in far greater detail than has been possible with conventional magnetic fields. However, the present use of ultra-high-field MR imaging is often limited by technical issues, such as increased inhomogeneity of both the main magnetic field and the applied RF field, increased RF power deposition within subjects, changes in relaxation behavior, enhanced susceptibility to subjects’ motion, and prominent physiological noise. These issues cause conventional imaging techniques to be difficult or even impossible to use.

My research focuses on developing new techniques, as well as improving existing techniques, for MR imaging at 7 Tesla in order to offer neuroscientists citing new possibilities to explore the human brain using this powerful tool. Specifically, my current work includes: (1) determining the optimal combinations of pulse sequences and acquisition parameters at specific scanner configurations, adapted to each experimental design, (2) developing novel imaging methods that overcome the technical challenges of ultra-high-field MR imaging, and (3) investigating practical methodologies for objective image quality assessment. Recently, I have also been interested in quantitative MR imaging at 7 Tesla. In addition, I am hoping to take advantage of my clinical experience as a medical physicist in order to establish quality control and quality assurance procedures for the 7 Tesla MR scanner to ensure proper performance as a reliable tool for neuroscience.

Selected Publications:

Yamada S, Ueguchi T, Ogata T, Mizuno H, Ogihara R, Koizumi M, Shimazu T, Murase K, Ogawa K. Radiotherapy treatment planning with contrast-enhanced computed tomography: feasibility of dual-energy virtual unenhanced imaging for improved dose calculations. Radiat Oncol. 9:168(1-10), 2014

Yagi M, Ueguchi T, Koizumi M, Ogata T, Yamada S, Takahashi Y, Sumida I, Akino Y, Konishi K, Isohashi F, Tomiyama N, Yoshioka Y, Ogawa K. Gemstone spectral imaging: determination of CT to ED conversion curves for radiotherapy treatment planning. J Appl Clin Med Phys. 14:173-186, 2013

Ogata T, Ueguchi T, Yagi M, Yamada S, Tanaka C, Ogihara R, Isohashi F, Yoshioka Y, Tomiyama N, Ogawa K, Koizumi M. Feasibility and accuracy of relative electron density determined by virtual monochromatic CT value subtraction at two different energies using the gemstone spectral imaging. Radiat Oncol. 8:83(1-5), 2013

Ueguchi T, Yamada S, Mihara N, Koyama Y, Sumikawa H, Tomiyama N. Breast diffusion-weighted MRI: comparison of tetrahedral versus orthogonal diffusion sensitization for detection and localization of mass lesions. J Magn Reson Imaging. 33:1375-1381, 2011